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ritonavir will improve the amount or effect of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.elvitegravir/cobicistat/emtricitabine/tenofovir DF increases amounts of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.need to as a result be irrational. This proof may be generalized to indicate